CITY THERAPEUTICS

City Therapeutics, Inc. is a clinical-stage biotechnology company developing the next generation of RNA interference (RNAi) therapeutics. The Company's pipeline of RNAi therapeutics is designed to achieve potent, specific, and durable suppression of disease-relevant hepatic and extrahepatic targets to treat diseases with significant unmet medical needs. The Company's product candidate, CITY-Factor XI (FXI), is a city-engineered GalNAc-conjugated small interfering RNA (siRNA) therapeutic targeting FXI for the prevention and treatment of thrombosis. Its second product candidate, CITY-RBP4, is a city-engineered GalNAc-conjugated siRNA therapeutic, in development for the treatment of Stargardt disease, which is the most common inherited macular degenerative disease in children and young adults, and other ocular diseases. Its third program, CITY-TFR2, is a city-engineered GalNAc-conjugated siRNA therapeutic candidate in development for anemia of chronic disease.